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The compounds within the ChemBridge and ChemDiv libraries were processed with the LigPrep module in Schrödinger. Then, the Glide module with XP scoring was used to dock these compounds within the binding web sites of 8 MIF buildings, and the a thousand major-rated compounds were being then rescored by the best Bayesian classifier.
MIF could be a legitimate therapeutic focus on in genitourinary malignancies; inhibiting MIF-mediated pathways that right market tumorigenesis or those that increase immunotherapy may be clinically beneficial.
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